Xuejun Wang Selected Research

Proteostasis Deficiencies

1/2019	PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
12/2017	TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux.
1/2016	The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart.
3/2015	Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil.
7/2013	Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.
12/2011	Proteasome functional insufficiency in cardiac pathogenesis.
11/2011	Autophagy and p62 in cardiac protein quality control.
9/2011	Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice.
7/2011	Autophagy and p62 in cardiac proteinopathy.
2/2011	The role of the proteasome in heart disease.

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Xuejun Wang Research Topics

Disease

43	Neoplasms (Cancer) 06/2022 - 09/2004
21	Cardiomyopathies (Cardiomyopathy) 12/2018 - 11/2003
14	Heart Diseases (Heart Disease) 01/2020 - 12/2002
14	Proteostasis Deficiencies 01/2019 - 05/2009
13	Heart Failure 01/2022 - 02/2006
9	Infections 01/2022 - 04/2012
9	Myocardial Ischemia (Ischemic Heart Diseases) 12/2018 - 09/2011
9	Cardiomegaly (Heart Hypertrophy) 08/2015 - 01/2005
7	COVID-19 01/2022 - 12/2020
7	Cardiotoxicity 01/2021 - 12/2005
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2010
7	Stomach Neoplasms (Stomach Cancer) 01/2021 - 01/2011
6	Reperfusion Injury 01/2021 - 11/2011
6	Necrosis 01/2021 - 01/2011
6	Prostatic Neoplasms (Prostate Cancer) 05/2019 - 05/2009
6	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 12/2017 - 12/2002
5	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2017 - 01/2014
4	Neoplasm Metastasis (Metastasis) 01/2021 - 02/2014
4	Hypoxia (Hypoxemia) 01/2021 - 01/2013
4	Pathologic Processes 01/2021 - 12/2011
4	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 04/2014
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2019 - 01/2017
4	Leukemia 09/2018 - 11/2014
4	Hypertension (High Blood Pressure) 06/2013 - 06/2003
4	Hypertrophy 09/2007 - 12/2002
3	Ischemic Stroke 01/2022 - 02/2014
3	Body Weight (Weight, Body) 01/2022 - 09/2007
3	Inflammation (Inflammations) 01/2022 - 05/2011
3	Ischemia 01/2021 - 12/2004
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 11/2005
3	Multiple Myeloma 01/2018 - 06/2014
3	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 05/2009
3	Lymphatic Metastasis 02/2017 - 02/2014
3	Desmin-Related Myofibrillar Myopathy 02/2006 - 12/2004
2	Myocardial Infarction 01/2022 - 07/2017
2	Stroke (Strokes) 01/2022 - 02/2014
2	Hypospadias 01/2022 - 01/2019
2	Chronic Hepatitis B 01/2022 - 11/2021
2	Hyperbilirubinemia 01/2021 - 01/2017
2	Kernicterus 01/2021 - 01/2020
2	Fibrosis (Cirrhosis) 01/2020 - 01/2013
2	Breast Neoplasms (Breast Cancer) 05/2019 - 09/2018
2	Colorectal Neoplasms (Colorectal Cancer) 04/2019 - 10/2018
2	Atherosclerosis 03/2019 - 01/2012

Drug/Important Bio-Agent (IBA)

53	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 09/2004
51	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2002
22	UbiquitinIBA 01/2022 - 04/2006
15	DesminIBA 12/2017 - 12/2002
12	Deubiquitinating EnzymesIBA 05/2019 - 06/2014
9	Ubiquitinated ProteinsIBA 12/2018 - 11/2005
8	Pharmaceutical PreparationsIBA 01/2021 - 07/2014
7	Crystallins (Crystallin)IBA 01/2021 - 12/2002
7	Proteasome InhibitorsIBA 01/2020 - 01/2012
6	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2012
6	Protein AggregatesIBA 01/2021 - 04/2006
6	Messenger RNA (mRNA)IBA 12/2017 - 01/2012
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2021 - 12/2005
5	Auranofin (Ridaura)FDA Link 03/2019 - 07/2014
5	Bortezomib (Velcade)FDA Link 09/2018 - 01/2013
5	CaspasesIBA 01/2018 - 01/2014
5	Imatinib Mesylate (Gleevec)FDA Link 01/2017 - 01/2014
5	gambogic acidIBA 04/2015 - 01/2013
4	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 09/2016
4	Biological ProductsIBA 01/2021 - 05/2016
4	BilirubinIBA 01/2021 - 01/2017
4	Peptides (Polypeptides)IBA 01/2021 - 01/2020
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 01/2013
4	Androgen Receptors (Androgen Receptor)IBA 05/2019 - 01/2017
4	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 06/2014
4	GoldIBA 01/2018 - 07/2014
3	Transcription Factors (Transcription Factor)IBA 06/2022 - 01/2016
3	Nucleic AcidsIBA 01/2022 - 10/2021
3	salicylhydroxamic acid (SHAM)IBA 01/2022 - 12/2008
3	Antiviral Agents (Antivirals)IBA 11/2021 - 04/2012
3	Cullin Proteins (Cullins)IBA 01/2021 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2016
3	Coordination ComplexesIBA 01/2018 - 06/2014
3	CopperIBA 01/2018 - 06/2014
3	bcr-abl Fusion ProteinsIBA 01/2017 - 01/2014
3	ATP dependent 26S protease (26S proteasome)IBA 09/2016 - 05/2009
3	Antirheumatic Agents (DMARD)IBA 11/2014 - 07/2014
2	ChromatinIBA 06/2022 - 01/2012
2	CytokinesIBA 01/2022 - 10/2014
2	Small Heat-Shock ProteinsIBA 01/2021 - 07/2010
2	Ligases (Synthetase)IBA 01/2021 - 01/2016
2	AlbuminsIBA 01/2021 - 01/2020
2	Indicators and Reagents (Reagents)IBA 01/2020 - 05/2014
2	ErbB Receptors (EGF Receptor)IBA 08/2019 - 04/2019
2	enzalutamideIBA 05/2019 - 04/2019
2	Small Interfering RNA (siRNA)IBA 05/2019 - 01/2016
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2019 - 12/2017
2	cytidylyl-(3'-5')-cytidine (CpC)IBA 12/2018 - 11/2018
2	HMGB1 Protein (HMG1)IBA 12/2018 - 11/2018
2	Oncogene Proteins (Oncogene Protein)IBA 10/2018 - 01/2017

Therapy/Procedure

19	Therapeutics 10/2021 - 12/2005
6	Drug Therapy (Chemotherapy) 01/2021 - 04/2015
6	Gastrectomy 01/2021 - 06/2013
4	Photothermal Therapy 01/2020 - 10/2017
2	Ligation 01/2022 - 07/2017
2	Lasers (Laser) 01/2020 - 11/2018